Some VST plugins like Native Instruments Kontakt and UVI Workstation can be used in standalone mode. From “holy grail” pianos to stunning keyboards you didn’t even know existed, this is a keyboardist’s dream come true. Others like Spectrasonics Omnisphere and Keyscape can only be used inside a DAW or host software like Ableton Live or Apple MainStage. I read that Spectrasonics is gonna release a standalone app. None of them come close to playing an actual grand so I guess ultimately it's whether or not it has the sound you're looking for in your music.
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